SUCCESSFUL TREATMENT OF. JUVENILE CHRONIC ARTHRITIS WITH A SPECIFIC ANTIVIRAL AGENT
Identifieur interne : 002143 ( Main/Exploration ); précédent : 002142; suivant : 002144SUCCESSFUL TREATMENT OF. JUVENILE CHRONIC ARTHRITIS WITH A SPECIFIC ANTIVIRAL AGENT
Auteurs : M. H. Pritchard ; Julia MunroSource :
- Rheumatology [ 1462-0324 ] ; 1989.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Anticorps antiviraux, Facteur rhumatoïde.
- immunologie : Virus de la grippe A.
- sang : Arthrite juvénile.
- traitement médicamenteux : Arthrite juvénile.
- usage thérapeutique : Amantadine.
- Adulte, Femelle, Humains, Induction de rémission, Méthode en double aveugle, Placebo, Récidive.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Antibodies, Viral, Rheumatoid Factor.
- chemical , therapeutic use : Amantadine.
- blood : Arthritis, Juvenile.
- drug therapy : Arthritis, Juvenile.
- immunology : Influenza A virus.
- Adult, Double-Blind Method, Female, Humans, Placebos, Recurrence, Remission Induction.
Abstract
In a previous paper we identified a group of patients with teenage onset chronic progressive arthritis (JCA or JRA) with raised antibody titres to influenza A (H2N2), an epidemic of which was present in the year they were born. On the basis that they might be chronic carriers of influenza A, and that this might be related to their arthropathy, it was decided to use the anti-influenza A drug amantadine to treat the virus and observe whether there was any effect on the joint disease. A 4-month, double-blind, placebo-controlled trial followed by a 4-month open study showed that amantadine could under these circumstances be of considerable therapeutic benefit while having no effect on patients without elevated antibody titres against influenza A.
Url:
DOI: 10.1093/rheumatology/28.6.521
Affiliations:
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JUVENILE CHRONIC ARTHRITIS WITH A SPECIFIC ANTIVIRAL AGENT</title><author><name sortKey="Pritchard, M H" sort="Pritchard, M H" uniqKey="Pritchard M" first="M. H." last="Pritchard">M. H. 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On the basis that they might be chronic carriers of influenza A, and that this might be related to their arthropathy, it was decided to use the anti-influenza A drug amantadine to treat the virus and observe whether there was any effect on the joint disease. A 4-month, double-blind, placebo-controlled trial followed by a 4-month open study showed that amantadine could under these circumstances be of considerable therapeutic benefit while having no effect on patients without elevated antibody titres against influenza A.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Munro, Julia" sort="Munro, Julia" uniqKey="Munro J" first="Julia" last="Munro">Julia Munro</name><name sortKey="Pritchard, M H" sort="Pritchard, M H" uniqKey="Pritchard M" first="M. H." last="Pritchard">M. H. Pritchard</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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